A scientist named Jack Griffin discovers a serum that renders human flesh invisible. He tests it on himself, but the drug also affects his mind, leaving him unable to reverse the change and increasingly violent as he searches for a way back to normal. Wrapped in bandages to conceal his condition, he takes refuge in a country inn, where his strange appearance and behavior draw unwanted attention. James Whale directed the film, which Universal Pictures released in late 1933, and it sits between Frankenstein and Bride of Frankenstein in his filmography. The screenplay was written by R.C. Sherriff, Philip Wylie and Preston Sturges, with Carl Laemmle Jr. producing. Claude Rains plays Griffin, his first major screen role, appearing largely through voice and bandaged silhouette. Gloria Stuart, William Harrigan, Henry Travers, Una O'Connor and Forrester Harvey round out the credited cast of 42.
The film runs 71 minutes and was adapted from H. G. Wells's 1897 novel, the story of a researcher whose experiment costs him his stability and eventually his life. Its ratings are consistent across audiences and critics: 7.6 out of 10 on IMDb from about 44,000 votes, 7.5 out of 10 on TMDB from roughly 1,000 votes, and 8.5 out of 10 from 59 critics' reviews, so professional reviewers rate it somewhat higher than general viewers do. Together with Whale's other horror work of the period, it belongs to Universal's classic horror cycle, and its sustained approval decades after release reflects its standing among early sound-era genre films.
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