Stu Miley is a cartoonist on the verge of a breakthrough, thanks to his creation Monkeybone, an unruly ape whose crude humour and mischief have made the character a hit. On the night he plans to propose to his girlfriend Julie, a car accident puts Stu in a coma. He wakes inside Downtown, a limbo between life and death populated by strange figures, among them his own alter ego. When Monkeybone tricks him and returns to the living world in Stu's body, Stu must find a way back before his body is used to cause chaos and before the decision is made to let him go.
Henry Selick directed the film, his third feature after The Nightmare Before Christmas and James and the Giant Peach; Coraline and Wendell & Wild came later in his filmography. Sam Hamm wrote the screenplay, with Mark Radcliffe and Michael Barnathan producing. Brendan Fraser plays Stu, Bridget Fonda appears as Dr. Julie McElroy, and John Turturro voices Monkeybone, alongside Chris Kattan, Giancarlo Esposito and Rose McGowan among a credited cast of 99.
Released in February 2001, the film cost about 75 million dollars and took roughly 8 million worldwide, a wide gap between spending and return. It holds a rating of 4.8 out of 10 on IMDb and 5.3 out of 10 on TMDB, while a critics' rating of 4.8 out of 10 from 112 reviews puts professional and audience responses at a similar level.
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