A scientist who has defected from behind the Iron Curtain is left comatose after an attempt on his life, suffering from a blood clot in his brain that no ordinary surgery can reach. American officials turn to a daring experimental procedure: a submarine and its crew of medical specialists are reduced to microscopic size and injected into the man's bloodstream, with the mission of destroying the clot from within. The crew has only a limited window before the miniaturization wears off and they return to normal size, and the dangers of the body itself are matched by suspicions that someone aboard is working against the mission.
Richard Fleischer directed the film, the ninth of the twenty-three features listed in his filmography, arriving between Barabbas and Doctor Dolittle. Harry Kleiner wrote the screenplay and Saul David produced it for 20th Century Fox. Stephen Boyd leads the cast as Grant, alongside Raquel Welch as Cora, Edmond O'Brien as General Carter and Donald Pleasence as Dr. Michaels, with Arthur O'Connell and William Redfield also appearing.
Released in August 1966, the film cost about 5 million dollars and took roughly 12 million worldwide. On IMDb it holds 6.8 from around 23,000 votes, on TMDB 6.7 from over 500 votes, while a critics' rating of 6.9 from 35 reviews places professional and audience assessments close together.
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