Set during the Gold Rush era, The Sisters Brothers follows two hired killers, Eli and Charlie, who work for a powerful figure known only as the Commodore. He sends them after Hermann Kermit Warm, a chemist and would-be prospector travelling toward California with a secret the Commodore wants for himself. As the brothers make their way from Oregon toward the goldfields near Sacramento, their pursuit is complicated by a scout who seems to be tracking the same man, and by Eli's growing doubts about the life he and his brother lead. Charlie takes to violence readily, while Eli imagines something else for himself, and the journey tests the bond between them.
Jacques Audiard directed and co-wrote the film with Thomas Bidegain, following Dheepan in his filmography and preceding Paris, 13th District. John C. Reilly, who plays Eli, also produced, alongside Michael De Luca and Pascal Caucheteux. Joaquin Phoenix plays Charlie, with Jake Gyllenhaal as John Morris and Riz Ahmed as Warm. The production was a European and American co-production made for a reported 38 million dollars and released in September 2018.
On IMDb, viewers rate it 6.9 out of 10 from roughly 75,000 votes, while on TMDB it holds 6.8 from over 2,000 ratings. A critics' score of 7.4 from 211 reviews places it slightly above those audience figures. Its worldwide box office return of about 13 million dollars fell short of its budget.
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